Anti-TICAM1 (N-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse
Host Species	Rabbit
Accession Number	Q8IUC6
Gene Id	148022
Gene Symbols	TICAM1
Protein Name / Synonyms	TICAM1 (N-term)
Clonality	Polyclonal
Preparation	This TICAM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 115-143 amino acids from the N-terminal region of human TICAM1.
Concentration (lot specific)	0.500 mg/ml
Recommended Applications	Western Blotting
Research Area	Cancer, Inflammation, Autophagy
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.

Specificity

Other Names

TICAM1;PRVTIRB; TRIF; TIR domain-containing adapter molecule 1; TIR domain-containing adapter molecule 1; Proline-rich, vinculin and TIR domain-containing protein B; TIR domain-containing adapter molecule 1; Putative NF-kappa-B-activating protein 502H; TIR domain-containing adapter molecule 1; Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta

NCBI Accession #

NP_891549.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

76422

Recommended Dilutions

WB: 1:1000

TICAM1 Antibody (N-term) (Cat# 102-14831) western blot analysis in Ramos cell line and mouse liver tissue lysates (35ug/lane).This demonstrates the TICAM1 antibody detected the TICAM1 protein (arrow).

Antigen Source

Human

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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