TIMP-1, TIMP-2, TIMP-3 and TIMP-4 (for tissue inhibitor of metalloproteinases-1, -2, -3 and -4) complex with metalloproteinases such as collagenases, gelatinases and stromelysins, resulting in irreversible inactivation of the metallo-proteinase. TIMP-1 was found to be identical to EPA (erythroidpotentiation activity). Parathyroid hormone has been shown to be a regulator of TIMP-2 in osteoblastic cells. TIMP-3 may be involved in regulating trophoblastic invasion of the uterus as well as in regulating remodeling of the extracellular matrix during the folding of epithelia, and in the formation, branching and expansion of epithelial tubes. TIMP-4 is most highly expressed in heart and low levels of TIMP-4 are expressed in liver, brain, lung, thymus and spleen.

The antibody can specifically bind to its immunogen, and did not show any cross reactivity with unrelated antigens as did in ELISA. The specificity for binding to recombinant protein, cellular protein and native antigen is not defined. Cross reactivity with mouse and rat TIMP3 has not yet been tested.

Store at -20°C, if not intended for use within a month, keep it at 4°C and minimize freezing and thawing when use.

Rabbit Anti-human TIMP3, Cat# RB-15-0001Recombinant Human TIMP3, Western Blot Control, Cat# RB-15-0001