Anti-TLR3 Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	O15455
Gene Id	7098
Gene Symbols	TLR3
Protein Name / Synonyms	TLR3
Clonality	Polyclonal
Preparation	This TLR3 antibody is generated from rabbits immunized with TLR3 recombinant protein.
Concentration (lot specific)	0.5 mg/ml
Recommended Applications	Western Blotting, IHC-P
Research Area	Angiogenesis, Cancer, Inflammation
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene.

Specificity

Other Names

TLR3; Toll-like receptor 3; CD_antigen=CD283; Flags: Precursor

NCBI Accession #

NP_003256.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

103829

Recommended Dilutions

WB: 1:1000; IHC: 1:50-100

	Western blot analysis of TLR3 Antibody (Cat# 102-12775) in HL-60 cell line lysates (35ug/lane). TLR3 (arrow) was detected using the purified Pab.
	Formalin-fixed and paraffin-embedded mouse brain tissue reacted with TLR3 Antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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