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Anti-TLR4 (Center) Antibody
Catalog #: 102-18356
Rabbit Anti-Human TLR4 (Center) Antibody, 400 ul
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | O00206 |
| Gene Id | 7099 |
| Gene Symbols | TLR4 |
| Protein Name / Synonyms | TLR4 (Center) |
| Clonality | Polyclonal |
| Preparation | This TLR4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 669-698 amino acids from the Central region of human TLR4. |
| Concentration (lot specific) | 0.5 mg/ml |
| Recommended Applications | Western Blotting, FC |
| Research Area | Cancer, Inflammation |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
TLR4 is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria.
Specificity
Predicted Reactivity
Bovine, Hamster, Pig
Other Names
TLR4; Toll-like receptor 4; hToll; CD_antigen=CD284; Flags: Precursor
NCBI Accession #
NP_003257.1;NP_612564.1;NP_612567.1
Other Accession #
Q68Y56; Q9WV82; Q9GL65
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
95680
Recommended Dilutions
WB: 1:1000; FC: 1:10-50
 | Western blot analysis of TLR4 Antibody (Center) (Cat# 102-18356) in HL-60 cell line lysates (35ug/lane). TLR4 (arrow) was detected using the purified Pab. |
 | TLR4 Antibody (Center) (Cat# 102-18356) flow cytometric analysis of U251 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.