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Anti-TNFR-S274 Antibody
Catalog #: 102-10966
Rabbit Anti-Human TNFR-S274 Antibody, 400 ul
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | P19438 |
| Gene Id | 7132 |
| Gene Symbols | TNFRSF1A |
| Protein Name / Synonyms | TNFR-S274 |
| Clonality | Polyclonal |
| Preparation | This TNFR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 252-281 amino acids from human TNFR. |
| Concentration (lot specific) | 0.5 mg/ml |
| Recommended Applications | Western Blotting, FC |
| Research Area | Apoptosis, Cancer, Inflammation |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease.
Specificity
Other Names
TNFRSF1A; TNFAR; TNFR1; Tumor necrosis factor receptor superfamily member 1A; Tumor necrosis factor receptor 1; Tumor necrosis factor receptor type I; p55; p60; CD_antigen=CD120a; Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1
NCBI Accession #
NP_001056.1
Other Accession #
NP_001056.1
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
50495
Recommended Dilutions
WB: 1:1000; FC: 1:10-50
 | hTNFR-pS274 (Cat# 102-10966) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the TNFR antibody detected the TNFR protein (arrow). |
 | TNFR-S274 Antibody (Cat# 102-10966) flow cytometric analysis of A549 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.