Rabbit Anti-Human TPA (Center) Antibody, 400 ul
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Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | P00750 |
| Gene Id | 5327 |
| Gene Symbols | PLAT |
| Protein Name / Synonyms | TPA (Center) |
| Clonality | Polyclonal |
| Preparation | This TPA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 371-399 amino acids from the Central region of human TPA. |
| Concentration (lot specific) | 2.0 mg/ml |
| Recommended Applications | Western Blotting, IHC-P, FC |
| Shipping Type | Blue ice |
| Storage | -20°C |
Introduction
TPA is a tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism.
Specificity
Other Names
PLAT; Tissue-type plasminogen activator; INN=Alteplase; INN=Reteplase; Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B
NCBI Accession #
NP_000921.1;NP_127509.1
Format
Type
Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
62917
Recommended Dilutions
WB: 1:1000; IHC: 1:10-50; FC: 1:10-50
 | Western blot analysis of TPA Antibody (Center) (Cat# 102-16932) in A2058 cell line lysates (35ug/lane). TPA (arrow) was detected using the purified Pab. |
 | TPA Antibody (Center) (RB18787) IHC analysis in formalin fixed and paraffin embedded human testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the TPA Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated. |
 | TPA Antibody (Center)? (Cat# 102-16932) flow cytometric analysis of A2058 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.