Anti-TPP1 (N-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	O14773
Gene Id	1200
Gene Symbols	TPP1
Protein Name / Synonyms	TPP1 (N-term)
Clonality	Polyclonal
Preparation	This TPP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6-34 amino acids from the N-terminal region of human TPP1.
Concentration (lot specific)	0.450 mg/ml
Recommended Applications	Western Blotting
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome.

Specificity

Predicted Reactivity

Monkey

Other Names

TPP1; CLN2; Tripeptidyl-peptidase 1; Cell growth-inhibiting gene 1 protein; Lysosomal pepstatin-insensitive protease; Tripeptidyl aminopeptidase; Tripeptidyl-peptidase I

NCBI Accession #

NP_000382.3

Other Accession #

Q60HH1; NP_000382.3

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

61248

Recommended Dilutions

WB: 1:1000

TPP1 Antibody (N-term) (Cat# 102-13248) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the TPP1 antibody detected the TPP1 protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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