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Anti-TRIM72 (C-term) Antibody
Catalog #: 102-11345
Rabbit Anti-Human TRIM72 (C-term) Antibody, 400 ul
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | Q6ZMU5 |
| Gene Id | 493829 |
| Gene Symbols | TRIM72 |
| Protein Name / Synonyms | TRIM72 (C-term) |
| Clonality | Polyclonal |
| Preparation | This TRIM72 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 299-327 amino acids from the C-terminal region of human TRIM72. |
| Concentration (lot specific) | 0.350 mg/ml |
| Recommended Applications | Western Blotting, IHC-P |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
TRIM72 is a muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity).
Specificity
Other Names
TRIM72; MG53; Tripartite motif-containing protein 72; Mitsugumin-53
NCBI Accession #
NP_001008275.2
Other Accession #
NP_001008275.2
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
52731
Recommended Dilutions
WB: 1:1000; IHC: 1:10-50
 | TRIM72 Antibody (C-term) (Cat# 102-11345) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the TRIM72 antibody detected the TRIM72 protein (arrow). |
 | TRIM72 Antibody (C-term) (Cat# 102-11345)immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TRIM72 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.