Anti-TSC2 (Center S1385/S1386) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P49815
Gene Id	7249
Gene Symbols	TSC2
Protein Name / Synonyms	TSC2 (Center S1385/S1386)
Clonality	Polyclonal
Preparation	This TSC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1364-1393 amino acids from the Central region of human TSC2.
Concentration (lot specific)	0.300 mg/ml
Recommended Applications	Western Blotting
Research Area	Cardiovascular Disease, Autophagy
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors.

Specificity

Predicted Reactivity

Mouse, Rat

Other Names

TSC2;TSC4; Tuberin; Tuberin; Tuberous sclerosis 2 protein

NCBI Accession #

NP_000539.2;NP_001070651.1;NP_001107854.1

Other Accession #

P49816; Q61037

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

200608

Recommended Dilutions

WB: 1:1000

TSC2 Antibody (Center S1385/S1386) (Cat# 102-14664) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the TSC2 antibody detected the TSC2 protein (arrow).

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

Featured Products