Anti-TTR (C-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P02766
Gene Id	7276
Gene Symbols	TTR
Protein Name / Synonyms	TTR (C-term)
Clonality	Polyclonal
Preparation	This TTR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-98 amino acids from the C-terminal region of human TTR.
Concentration (lot specific)	0.400 mg/ml
Recommended Applications	FC, IHC-P, Western Blotting, IF
Research Area	Cardiovascular Disease
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc.

Specificity

Predicted Reactivity

Monkey

Other Names

TTR; PALB; Transthyretin; ATTR; Prealbumin; TBPA

NCBI Accession #

NP_000362.1

Other Accession #

Q8HXW1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

15887

Recommended Dilutions

IF: 1:25; WB: 1:1000; IHC: 1:50-100; FC: 1:10-50

	Immunofluorescent analysis of Human pancreas tissues and Human kidney tissues, using TTR Antibody (C-term) (Cat# 102-16894). 102-16894 was diluted at 1:25 dilution. Alexa Fluor 488-conjugated goat anti-rabbit lgG at 1:400 dilution was used as the secondary antibody (green). DAPI was used to stain the cell nuclear (blue).
	TTR Antibody (C-term) (Cat# 102-16894) western blot analysis in human blood plasma tissue lysates (35ug/lane).This demonstrates the TTR antibody detected the TTR protein (arrow).
	TTR Antibody (C-term) (RB19657) IHC analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the TTR Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
	TTR Antibody (C-term) (Cat# 102-16894) flow cytometric analysis of A375 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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