Anti-Ubiquilin1 (PLIC1) (N-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse
Host Species	Rabbit
Accession Number	Q9UMX0
Gene Id	29979
Gene Symbols	UBQLN1
Protein Name / Synonyms	Ubiquilin1 (PLIC1) (N-term)
Clonality	Polyclonal
Preparation	This Ubiquilin1 (PLIC1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-49 amino acids from the N-terminal region of human Ubiquilin1 (PLIC1).
Concentration (lot specific)	2.0 mg/ml
Recommended Applications	Western Blotting, IHC-P
Research Area	Autophagy
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

PLIC1 is an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and is found in lesions associated with Alzheimer's and Parkinson's disease.

Specificity

Predicted Reactivity

Rat

Other Names

UBQLN1; DA41; PLIC1; Ubiquilin-1; Protein linking IAP with cytoskeleton 1

NCBI Accession #

NP_038466.2;NP_444295.1

Other Accession #

Q9JJP9; Q8R317

Format

Type

Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

62519

Recommended Dilutions

WB: 1:1000; IHC: 1:50-100

	PLIC1 Antibody (P34) (Cat# 102-15007) western blot analysis in SH-SY5Y,U87-MG cell line lysates (35ug/lane).This demonstrates the PLIC1 antibody detected the PLIC1 protein (arrow).
	Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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