Anti-UVRAG (L133) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse
Host Species	Rabbit
Accession Number	Q9P2Y5
Gene Id	7405
Gene Symbols	UVRAG
Protein Name / Synonyms	UVRAG (L133)
Clonality	Polyclonal
Preparation	This UVRAG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 120-152 amino acids from human UVRAG.
Concentration (lot specific)	2.000 mg/ml
Recommended Applications	Western Blotting, IF, IHC-P
Research Area	Autophagy
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

UVRAG complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer.

Specificity

Other Names

UVRAG; UV radiation resistance-associated gene protein; p63

NCBI Accession #

NP_003360.2

Format

Type

Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

78151

Recommended Dilutions

WB: 1:1000; IF: Tested; IHC: 1:10-50

	Western blot analysis of anti-hUVRAG (Center) Pab (RB10846) in mouse liver tissue lysate. hUVRAG (Center)(arrow) was detected using the purified Pab.
	Immunofluorescence staining of Autophagy UVRAG antibody (Cat# 102-13880) on Methanol-fixed HeLa cells. Data courtesy of Dr. Eeva-Liisa Eskelinen, University of Helsinki,Finland.
	Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with hUVRAG (N-term L133), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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