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Anti-WRN (Center T802) Antibody
Catalog #: 102-11388
Rabbit Anti-Human WRN (Center T802) Antibody, 400 ul
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | Q14191 |
| Gene Id | 7486 |
| Gene Symbols | WRN |
| Protein Name / Synonyms | WRN (Center T802) |
| Clonality | Polyclonal |
| Preparation | This WRN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 787-816 amino acids from the Central region of human WRN. |
| Concentration (lot specific) | 0.5 mg/ml |
| Recommended Applications | Western Blotting, FC |
| Research Area | Cancer |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging.
Specificity
Other Names
WRN; RECQ3; RECQL2; Werner syndrome ATP-dependent helicase; DNA helicase, RecQ-like type 3; Exonuclease WRN; RecQ protein-like 2
NCBI Accession #
NP_000544.2
Other Accession #
NP_000544.2
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
162461
Recommended Dilutions
WB: 1:1000; FC: 1:10-50
 | WRN Antibody (Center T802) (Cat# 102-11388) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the WRN antibody detected the WRN protein (arrow). |
 | WRN Antibody (Center T802) (Cat# 102-11388) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.