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Anti-XIAP Antibody, Biotinylated
Catalog #: 130-10056B-50
Rabbit anti-XIAP Biotinylated Antibody, 50 ug
Product Description
Specifications
| Size | 50 µg |
| Estimated Lead Time | 1-2 business days |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | P98170 |
| Gene Id | 331 |
| Gene Symbols | XIAP API3 BIRC4 IAP3 |
| Clonality | Polyclonal |
| Immunogen | Immunogen was synthetic peptide derived from human XIAP. This antibody was produced from a rabbit immunized with the immunogen. The IgG fraction was purified from rabbit serum by ammonium sulphate precipitation, and followed by Protein A/G affinity chromatography. |
| Isotype | IgG |
| Recommended Applications | ELISA (recommended work dilution= 1: 32, 000(at least detecting 31 µg/ml)) |
| Reconstitution | A separate vial of dilution buffer is provided for reconstitution. The antibody is supplied lyophilized, originally containing PBS, without preservative stabilizers (e.g. sodium azide). The final amount is indicated on the shipping vial. |
| Research Area | Apoptosis, Cancer, Inflammation |
| Shipping Type | Ambient temperature |
| Storage | -20°C |
Description
Description
XIAP is an apoptotic suppressor which has E3 ubiquitin-protein ligase activity. XIAP mediates the proteasomal degradation of target proteins, such as caspase-3, SMAC or AIFM1, inhibit caspase-3, -7 and -9. Mediates activation of MAP3K7/TAK1, leading to the activation of NF-kappa-B. Defects in XIAP are the cause of lymphoproliferative syndrome X-linked type 2 (XLP2). XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma.
Storage / Stability
The antibody is stable for at least 1 year from the date of receipt when stored at -20°C to -70°C. Reconstituted antibody can also be aliquotted and stored at 4°C for 1 month or at -20°C to -70°C in a manual defrost freezer for many months without detectable loss activity. Please avoid freeze-thaw cycles.
Specificity
The antibody can specifically bind to its immunogen, and did not show any cross reactivity with unrelated antigens in ELISA. The specificity for binding to recombinant protein, cellular protein and native antigen is not defined. Cross reactivity with mouse and rat XIAP has not yet been tested.
References
- Galb¡n S,et al.. (2010) XIAP as a ubiquitin ligase in cellular signaling. Cell Death Differ. 17(1):54-60.
- Danson S, et al.. (2007) Ranson M. IAPs as a target for anticancer therapy. Curr Cancer Drug Targets. 7(8):785-94.
Expiration:
12 months from the date of shipment when stored properly.