Signal transducer and activator of transcription 2 is a protein that in humans is encoded by the STAT2 gene.The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (IRF9), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus.STAT2-PY is the phosphorylated form of STAT2 protein.

The antibody is stable for at least 1 year from the date of receipt when stored at -20^°C to -70^°C. Reconstituted antibody can also be aliquotted and stored at 4^°C for 1 month or at -20^°C to -70^°C in a manual defrost freezer for many months without detectable loss activity. Please avoid freeze-thaw cycles.