Mouse Anti-HPV 16 Oncoprotein E7

Mouse Anti-HPV 16 Oncoprotein E7

$488.00
DS-MB-03401
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Antigen Information

Protein Name & Synonyms:
HPV 16 Oncoprotein E7
Target Species:
  • Viral

Antibody Specifications

Applications:
ELISA, Western Blotting
Concentration:
IgG concentration 1.0mg/ml
Species Reactivity:
Viral

Specificity

This product recognizes both the monomer and dimer forms of the E7 oncoprotein of human papilloma virus 16. Human papillomavirus (HPV) is a diverse group of DNA-based viruses that infect skin and mucous membranes of humans and animals. Some HPV types are the causative agents of cervical cancer, with types 16 and 18 being particularly high-risk. The viral proteins E6 and E7 disrupts normal cell cycle regulation by interacting with p53 (a tumor-suppressing transcription factor) and Rb (retinoblastoma protein, also a tumor-supressor). E7 particularly binds to Rb and histone deacetylases, resulting in activation of the E2F genes, which code for a family of transcription factors. The viral proteins E6 and E7 might be of particular interest in the development of therapeutic vaccines, since they are expressed early in viral infection.

This product cross-reacts with both the monomer and dimer forms of the E7 protein of HPV-18.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified

Preparation

Immunogen:
Oncoprotein E7 from human papillomavirus 16.
Preservative:
0.09% Sodium azide

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.