Mouse Anti-Human C3c

Mouse Anti-Human C3c

$558.00
DS-MB-00151
+

Antigen Information

Protein Name & Synonyms:
C3c
Target Species:
  • Human

Antibody Specifications

Applications:
Immunohistology - Frozen, ELISA, Flow Cytometry, Western Blotting
Concentration:
IgG concentration 1.0mg/ml
Species Reactivity:
Human

Specificity

This product recognizes 135kDa complement component 3c (C3c), present in blood serum. C3c is generated over the course of complement activation, where convertase C4b2a (classical pathway) and convertase C3bBb (alternative pathway) cleave C3 to C3b and C3a. C3b is further degraded into iC3b and C3dg/C3d. iC3b is then slowly cleaved (possibly by factor I) to form C3c (beta chain + alpha' chain fragment 1 + alpha' chain fragment 2), C3dg and C3f.

C3 is crucial in the induction of tolerance generated when an antigen is introduced into immunoprivileged sites and this is exploited by pathogens and cancer cells to evade the immune system by inhibiting complement activation.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
Borate buffered saline
Format Type:
Purified

Preparation

Immunogen:
Human C3 from normal serum, highly purified by chromatography.
Preservative:
0.09%Sodium Azide (NaN3)

No posts found

Write A Review
U.S. Non-U.S.

Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.