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Antigen Information
Protein Name & Synonyms:
C4c
Target Species:
- Human
Antibody Specifications
Applications:
Immunohistology - Frozen, ELISA, Flow Cytometry, Western Blotting
Concentration:
1.0mg/ml
Species Reactivity:
Human
HAZARD
DANGER - this product contains DISODIUM TETRABORATE DECAHYDRATE, BORIC ACID. May damage fertility. May damage the unborn child.
Specificity
This product recognizes complement component 4c (C4c). The complement 1 complex cleaves complement 4 (C4) to form C4b and C4a. C4b levels are strictly regulated. Single site cleavage of the C4b❏'s alpha chain by Factor I forms iC4b and blocks C3 convertase, inhibiting opsonisation and activation of the classical pathway. iC4b is further degraded into the inactive fragments C4d and C4c. C4c consists of two a-chain fragments, alpha 4 (13 kDa) and alpha 3 (25 kDa) linked to a beta chain through disulphide bridges and a gamma chain. It is expressed in the blood plasma.
Storage/Stability
Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.
Format
HAZARD
DANGER - HARMFUL IF SWALLOWED. - This product contains DISODIUM TETRABORATE DECAHYDRATE, BORIC ACID. May damage fertility. May damage the unborn child.
Supplied as:
Purified IgG - liquid
Formulation:
Borate buffered saline
Format Type:
Purified
Preparation
Immunogen:
Purified human C4c
Preservative:
| 0.09% | Sodium Azide (NaN3) |
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Usage
This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.
