Mouse Anti-Human C4d

Mouse Anti-Human C4d

DS-MB-00163
+

Antigen Information

Protein Name & Synonyms:
C4d
Target Species:
  • Human

Antibody Specifications

Applications:
Immunohistology - Frozen, ELISA (dilution: 1/250, 1/600), Immunofluorescence, Immunohistology - Paraffin, Western Blotting
Concentration:
IgG concentration 1.0 mg/ml
Species Reactivity:
Human

Specificity

This product recognizes the secreted protein complement component 4d (C4d). The complement 1 complex cleaves complement 4 (C4) to form C4b and C4a. C4b levels are strictly regulated. Single site cleavage of the C4b❏'s alpha chain by Factor I forms iC4b and blocks C3 convertase, inhibiting opsonisation and activation of the classical pathway. This requires C4 binding protein or CR1 as a cofactor. iC4b is further degraded into C4d and C4c. C4d❏'s short half life means that C4d is present in serum at high enough concentrations to make it a useful marker for classical complement activation.

C4 has been linked to susceptibility to systemic lupus erythematosous.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted.
Avoid repeated freezing and thawing as this may denature the antibody.
Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
Borate buffered saline
Format Type:
Purified

Preparation

Immunogen:
Native, from human plasma
Preservative:
0.09%Sodium Azide (NaN3)

No posts found

Write A Review
U.S. Non-U.S.

Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.