Mouse Anti-Human CD257

Mouse Anti-Human CD257 (0.5 mg)

DS-MB-02946
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Antigen Information

Protein Name & Synonyms:
CD257
Target Species:
  • Human

Antibody Specifications

Applications:
ELISA (dilution: 5, 6ug/ml)
Concentration:
IgG concentration 1.0mg/ml after reconstitution.
Reconstitution:
Reconstitute with 0.5ml distilled water
Species Reactivity:
Human

Specificity

This product specifically recognizes CD257 (otherwise known as BAFF/BLyS), a 285 amino acid type II transmembrane protein and member of the tumor necrosis factor (TNF) superfamily of ligands, which acts as a B and T cell stimulator and plays a role in the development of autoimmune diseases such as systemic lupus erythematosus.

CD257 is expressed by monocytes, macrophages, T cells and dendritic cells and acts through binding to CD267 (TACI), CD269 (BCMA) and CD268 (BAFFR) receptors, the latter interaction playing a critical role in the activation, survival, differentiation and proliferation of B cells.

This antibody has not been cross-adsorbed and may react with homologous proteins from related species.

Storage/Stability

Prior to reconstitution store at +4 °C.
After reconstitution store at -20 °C.
Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 12 months after receipt.

Format

Supplied as:
Purified IgG - lyophilized
Formulation:
Phosphate buffered saline
Reconstitution:
Reconstitute with 0.5ml distilled water
Format Type:
Purified

Preparation

Immunogen:
Recombinant full-length mature human CD257 expressed in E. coli.
Preservative:
None present

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.