Protein Name & Synonyms:
Immunohistology - Frozen, Flow Cytometry, Immunoprecipitation
IgG concentration 1.0 mg/ml
Mouse anti Human CD86 antibody recognizes human CD86 also known as B7-2, a type I transmembrane protein expressed by monocytes and activated B cells. CD86 acts as a co - stimulaory molecule along with CD80 and is a ligand for CD28 and CTLA-4. CD86 is a member of the Immunoglobulin superfamily and carries an extracellular domain bearing both an Ig -v -like domain which contains the CTLA -4 binding site and an adjacent C2-like domain. CD86 plays an important role in co - stimulation of T cell proliferation , IL-2 production and in the primary immune response.
Domain depletion epitope mapping studies indicate that the binding site of Mouse anti Human CD86, clone Bu63 is located within the Ig -v -like domain of human CD86.
Studies suggest that CD86 along with CD80 may be exploited as receptors for adenovirus entry into cells.
Store at +4 °C or at -20 °C if preferred.
This product should be stored undiluted.
Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.
Purified IgG - liquid
TRIS buffered saline
Human peripheral blood lymphocytes.
Spleen cells from immunised mice were fused with cells of the P3 X63 Ag8.653 myeloma cell line.