This antibody specifically recognizes the beta subunit of human chorionic gonadotropin (hCG).

Minimal cross­reactivity (0.5%) has been observed with the intact hCG molecule and negligible reactivity has been shown with the human luteinizing hormone (LH), follicle­ stimulating hormone (FSH) and thyroid­stimulating hormone (TSH).

Human chorionic gonadotropin exists in 5 different variants (hCG, sulfated hCG, hyperglycosylated hCG, free beta hCG and hyperglycosylated free beta) that share the same amino acid sequence but have different functions (Cole 2012). hCG is a glycoprotein of 237 amino acids. Regular hCG has a molecular weight of 36,000 where oligosaccharides account for 25-­30% of the MW (Cole 2010). It is composed of a 92­ amino acid alpha subunit, common to the LH, FSH and TSH hormones, and of a unique beta subunit, which is recognized by this antibody.

Production of progesterone is not the only role of hCG: it also has numerous other functions, during pregnancy and as a marker for certain cancers (Cole LA 2012, 2010 and 2009).

P01233

CGB3

IgG concentration 1.0 mg/ml