This IL1B antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 148-174 amino acids from the Central region of human IL1B.
Clonality
Monoclonal
Species
Human
Introduction
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq].
Specificity
Predicted Reactivity
Monkey, Rabbit
Other Names
IL1B; IL1F2; Interleukin-1 beta; Catabolin
NCBI Accession #
NP_000567.1
Other Accession #
P14628; P79182; NP_000567.1
Format
Type
Mouse Monoclonal Antibody (Mab)
Calculated Molecular Weight (Da)
30748
Recommended Dilutions
WB: 1:2000-4000
IL1B Antibody (Center)(Ascites)(Cat# 102-10345). 293 cell lysates transiently transfected with the IL1B gene.
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.
