This NOTCH3 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 2291-2321 amino acids from the C-terminal region of human NOTCH3.
Clonality
Monoclonal
Species
Human
Introduction
This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq].
Specificity
Other Names
NOTCH3; Neurogenic locus notch homolog protein 3; Notch 3 extracellular truncation; Notch 3 intracellular domain
NCBI Accession #
NP_000426.2
Other Accession #
NP_000426.2
Format
Type
Mouse Monoclonal Antibody (Mab)
Calculated Molecular Weight (Da)
243631
Recommended Dilutions
WB: 1:100-250
NOTCH3 Antibody (Q2306) (Cat# 102-10285) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the NOTCH3 antibody detected the NOTCH3 protein (arrow).
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.
