Nestin is a protein that in humans is encoded by the NES gene.Nestin is a type VI intermediate filament (IF) protein. It plays a role in regulation of the assembly and disassembly of intermediate filaments, which, together with other structural proteins, participate in remodeling of the cell. The role of nestin in dynamic cells, particularly structural organization of the cell, appears strictly regulated by phosphorylation, especially its integration into heterogeneous intermediate filaments together with vimentin or ?-internexin. Furthermore, nestin expression has been extensively used as a marker for central nervous system (CNS) progenitor cells in different contexts, based on observations indicating a correlation between nestin expression and this cell type in vivo.

The antibody is stable for at least 1 year from the date of receipt when stored at -20^°C to -70^°C. Reconstituted antibody can also be aliquotted and stored at 4^°C for 1 month or at -20^°C to -70^°C in a manual defrost freezer for many months without detectable loss activity. Please avoid freeze-thaw cycles.