Rabbit Anti-Human ACVR2A (N-term) Antibody, 400 ul
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Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | P27037 |
| Gene Id | 92 |
| Gene Symbols | ACVR2A |
| Protein Name / Synonyms | ACVR2A (N-term) |
| Clonality | Polyclonal |
| Preparation | This ACVR2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-29 amino acids from the N-terminal region of human ACVR2A. |
| Concentration (lot specific) | 2.0 mg/ml |
| Recommended Applications | Western Blotting |
| Shipping Type | Blue ice |
| Storage | -20°C |
Introduction
ACVR2A is an activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.
Specificity
Predicted Reactivity
Mouse, Rat, Bovine, Chicken
Other Names
ACVR2A; ACVR2; Activin receptor type-2A; Activin receptor type IIA
NCBI Accession #
NP_001265508.1;NP_001265509.1;NP_001607.1
Other Accession #
P38444; P27038; Q90669; Q28043
Format
Type
Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
57848
Recommended Dilutions
WB: 1:1000; IHC: 1:50-100
 | Western blot analysis of anti-ACVR2A Antibody (N-term) (Cat# 102-17131) in mouse liver(lane 1) brain(lane 2) and kidney(lane 3) tissue lysates (35ug/lane). ACVR2A (arrow) was detected using the purified Pab. |
 | Western blot analysis of ACVR2A (arrow) using rabbit polyclonal ACVR2A Antibody (N-term) (Cat# 102-17131). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the ACVR2A gene (Lane 2) (Origene Technologies). |
 | Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.