This Dnmt3A/Dnmt3A2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 723-752 amino acids from the C-terminal region of human Dnmt3A/Dnmt3A2.
Host Species
Rabbit
Clonality
Polyclonal
Species
Human
Introduction
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. DNMT3A is a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated.
Specificity
Predicted Reactivity
Mouse, Rat
Other Names
DNMT3A; DNA (cytosine-5)-methyltransferase 3A; DNA methyltransferase HsaIIIA
NCBI Accession #
NP_072046.2;NP_715640.2;NP_783328.1;NP_783329.1
Other Accession #
Q1LZ53; O88508
Format
Type
Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
101858
Recommended Dilutions
WB: 1:1000
Western blot analysis of DNMT3A Antibody (C-term) (Cat# 102-10604) in HepG2 cell line lysates (35ug/lane). DNMT3A (arrow) was detected using the purified Pab.
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.
