Rabbit Anti-PABPC1 (Center) Antibody, 400 ul
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Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human, Mouse |
| Host Species | Rabbit |
| Accession Number | P11940 |
| Gene Id | 26986 |
| Gene Symbols | PABPC1 |
| Protein Name / Synonyms | PABPC1 (Center) |
| Clonality | Polyclonal |
| Preparation | This PABPC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 250-279 amino acids from the Central region of human PABPC1. |
| Concentration (lot specific) | 2.000 mg/ml |
| Recommended Applications | Western Blotting, IHC-P |
| Shipping Type | Blue ice |
| Storage | -20°C |
Introduction
PABPC1 binds the poly(A) tail of mRNA. It may be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre-mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. PABPC1 can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. It may be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.
Specificity
Predicted Reactivity
Rat, Bovine, Xenopus
Other Names
PABPC1; PAB1; PABP1; PABPC2; Polyadenylate-binding protein 1
NCBI Accession #
NP_002559.2
Other Accession #
Q6IP09; P20965; Q9EPH8; P29341; P61286
Format
Type
Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
70671
Recommended Dilutions
WB: 1:1000; IHC: 1:50-100
 | Western blot analysis of PABPC1 Antibody (Center) (Cat# 102-15228) in NIH-3T3 cell line lysates (35ug/lane). PABPC1 (arrow) was detected using the purified Pab. |
 | Formalin-fixed and paraffin-embedded human lung carcinoma reacted with PABPC1 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.