Rabbit Anti-BACE1 (N-term) Antibody, 400 ul
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Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human, Mouse |
| Host Species | Rabbit |
| Accession Number | P56817 |
| Gene Id | 23621 |
| Gene Symbols | BACE1 |
| Protein Name / Synonyms | BACE1 (N-term) |
| Clonality | Polyclonal |
| Preparation | This BACE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-70 amino acids from the N-terminal region of human BACE1. |
| Concentration (lot specific) | 2.000 mg/ml |
| Recommended Applications | Western Blotting, IHC-P |
| Shipping Type | Blue ice |
| Storage | -20°C |
Introduction
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is BACE. This protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi.
Specificity
Predicted Reactivity
Rat, Bovine
Other Names
BACE1; BACE; KIAA1149; Beta-secretase 1; Aspartyl protease 2; Beta-site amyloid precursor protein cleaving enzyme 1; Memapsin-2; Membrane-associated aspartic protease 2
NCBI Accession #
NP_001193978.1;NP_036236.1;NP_620427.1;NP_620428.1;NP_620429.1
Other Accession #
P56819; P56818; Q2HJ40
Format
Type
Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
55711
Recommended Dilutions
WB: 1:1000; IHC: 1:10-50
 | Western blot analysis of anti-BACE1 Antibody (N-term) (Cat# 102-17615) in mouse heart tissue lysates (35ug/lane). BACE1(arrow) was detected using the purified Pab. |
 | Formalin-fixed and paraffin-embedded human brain tissue reacted with BACE1 antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.