Canis familiaris allergen 1 (Can f 1), which found in dog hair and dander extract, was a protein with molecular weight reported to range from 21 to 25 kD. It binds immunoglobulin E (IgE) from the majority of dog-allergic subjects.
Allergy to the domestic dog (Canis familiaris) is prominent worldwide. Dog allergens can be detected not only in houses where dogs are kept as pets but also in other places such as schools and day care centres where dogs are not present on a regular basis. Chronic exposure to dog and other indoor allergens, including mite and cat, may lead to allergic sensitization and contribute to the development of bronchial hyperreactivity and asthma in children.

The antibody can specifically bind to its immunogen, and did not show any cross reactivity with unrelated antigens in ELISA. The specificity for binding to recombinant protein, cellular protein and native antigen is not defined. Cross reactivity with the protein from other species has not yet been tested.

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