Mouse anti Human CD86 antibody recognizes human CD86 also known as B7-2, a type I transmembrane protein expressed by monocytes and activated B cells. CD86 acts as a co - stimulaory molecule along with CD80 and is a ligand for CD28 and CTLA-4. CD86 is a member of the Immunoglobulin superfamily and carries an extracellular domain bearing both an Ig -v -like domain which contains the CTLA -4 binding site and an adjacent C2-like domain. CD86 plays an important role in co - stimulation of T cell proliferation , IL-2 production and in the primary immune response.

Domain depletion epitope mapping studies indicate that the binding site of Mouse anti Human CD86, clone Bu63 is located within the Ig -v -like domain of human CD86.

Studies suggest that CD86 along with CD80 may be exploited as receptors for adenovirus entry into cells.

CD86