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Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | O14640 |
| Gene Id | 1855 |
| Gene Symbols | DVL1 |
| Protein Name / Synonyms | DVL1 (Center) |
| Clonality | Polyclonal |
| Preparation | This DVL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 442-470 amino acids from the Central region of human DVL1. |
| Concentration (lot specific) | 0.500 mg/ml |
| Recommended Applications | IF, IHC-P, Western Blotting |
| Research Area | Cardiovascular Disease |
| Shipping Type | Blue ice |
| Storage | -20°C |
Introduction
DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development.
Specificity
Predicted Reactivity
Mouse, Rat
Other Names
DVL1; Segment polarity protein dishevelled homolog DVL-1; DSH homolog 1
NCBI Accession #
NP_004412.2
Other Accession #
P54792; Q9WVB9; P51141; NP_004412.2
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
75187
Recommended Dilutions
WB: 1:1000; IHC: 1:10-50; IF: 1:10-50
 | DVL1 Antibody (Center) (Cat# 102-11509) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the DVL1 antibody detected the DVL1 protein (arrow). |
 | DVL1 Antibdy (Center) (Cat# 102-11509)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of DVL1 Antibdy (Center) for immunohistochemistry. Clinical relevance has not been evaluated. |
 | Confocal immunofluorescent analysis of DVL1 Antibody (Center) (Cat# 102-11509) with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue). |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.