This product is specific for human EGF (Epidermal Growth Factor), a potent stimulator and regulator of the proliferation of epidermal and epithelial cells, which is expressed by a variety of cells.<br >
The effects of EGF are initiated through tyrosine kinase activity, following the binding of EGF to the extracellular domain of the 170kDa EGF receptor (EGFR), which also binds other EGF-like ligands with high affinity, including TGF-α, VGF (vaccinia virus growth factor) and Betacellulin, produced by certain tumour cells. Receptor activation through EGF binding triggers several signal transduction pathways, including the JAK/STAT and P13K/AKT pathways.

EGF

IgG concentration 1.0mg/ml after reconstitution

Reconstitute with 0.1ml distilled water.For long term storage the addition of 0.09% sodium azide is recommended.N.B. For functional studies do not add azide.