This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease.

Store at -20°C. If intended for use within a month, may keep at 4°C. Minimize freeze-thaw cycles.

12 months from the date of shipment when stored properly.