Product Description

Specifications

Size	20 µg, 100 µg, 200 µg, 500 µg, 1 mg
Estimated Lead Time	1-2 business days
Species	Human
Host Species	Rabbit
Clonality	Polyclonal
Preparation	This antibody was produced from antiserum of rabbits immunized with a recombinant protein immunogen. The IgG fraction was purified by Protein A affinity chromatography.
Recommended Applications	ELISA (recommended work dilution = 1:5, 000)
Reconstitution	Product is supplied as a powder obtained from lyophilization of purified antibody in glycine solution. Reconstitute the antibody with sterile water to a final concentration of 1 mg/ml.
Shipping Type	Ambient temperature
Storage	-20°C

Description

N7-methylguanosine (m7G) is the most ubiquitous mRNA cap modification and is also present in internal mRNA, microRNA (miRNA), tRNA and rRNA. m7G is positively charged and produced by the methyltransferase-like 1 (METTL1) and WD repeat domain 4 (WDR4) complex. Emerging evidence suggests that the METTL1/WDR4 complex promoted or inhibited the processes of brain development and diseases, as well as many kinds of tumor, including head and neck, lung, liver, colon, bladder cancer, and teratoma. Additionally, m7G is also crucial for tumor chemoresistance, vasculogenesis and prognosis. Therefore, m7G modification can be used as biomarkers or potential intervention targets, providing new possibilities for early diagnosis and treatment of tumors.