Rabbit Anti-MLF1 (N-term) Antibody, 400 ul
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Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human, Mouse |
| Host Species | Rabbit |
| Accession Number | P58340 |
| Gene Id | 4291 |
| Gene Symbols | MLF1 |
| Protein Name / Synonyms | MLF1 (N-term) |
| Clonality | Polyclonal |
| Preparation | This MLF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 35-62 amino acids from the N-terminal region of human MLF1. |
| Concentration (lot specific) | 2.0 mg/ml |
| Recommended Applications | Western Blotting |
| Shipping Type | Blue ice |
| Storage | -20°C |
Introduction
MLF1 is involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. The protein interferes with erythopoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. It suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. It binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.
Specificity
Other Names
MLF1; Myeloid leukemia factor 1; Myelodysplasia-myeloid leukemia factor 1
NCBI Accession #
NP_001123628.1;NP_001123629.1;NP_001182361.1;NP_001182362.1;NP_001182363.1;NP_071888.1
Format
Type
Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
30627
Recommended Dilutions
WB: 1:1000
 | Western blot analysis of MLF1 Antibody (N-term) (Cat# 102-16905) in mouse heart tissue lysates (35ug/lane). MLF1 (arrow) was detected using the purified Pab. |
 | Western blot analysis of MLF1 (arrow) using rabbit polyclonal MLF1 Antibody (N-term) (Cat# 102-16905). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the MLF1 gene. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.