Rabbit Anti-Human SYVN1 (HRD1) (N-term) Antibody, 400 ul
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Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | Q86TM6 |
| Gene Id | 84447 |
| Gene Symbols | SYVN1 |
| Protein Name / Synonyms | SYVN1 (HRD1) (N-term) |
| Clonality | Polyclonal |
| Preparation | This SYVN1 (HRD1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-88 amino acids from the N-terminal region of human SYVN1 (HRD1). |
| Concentration (lot specific) | 2.0 mg/ml |
| Recommended Applications | Western Blotting |
| Shipping Type | Blue ice |
| Storage | -20°C |
Introduction
HRD1 is a ubiquitin ligase whose expression is induced by the unfolded protein response (UPR) following endoplasmic reticulum stress. Expression of HRD1 protects cells from apoptosis by inducing degradation of abnormally processed proteins that accumulate in the endoplasmic reticulum. HRD1 is expressed in many tissues, strongly expressed in brain, pancreas, liver, kidney and skeletal muscle. Synoviolin/Hrd1 (expressed in rheumatoid synovium) is reported to be a novel causative factor for arthropathy by triggering synovial cell outgrowth through its antiapoptotic effects. HRD1 contains one ring-type zinc finger.
Specificity
Predicted Reactivity
Mouse, Xenopus
Other Names
SYVN1; HRD1; KIAA1810; E3 ubiquitin-protein ligase synoviolin; Synovial apoptosis inhibitor 1
NCBI Accession #
NP_115807.1;NP_757385.1
Other Accession #
Q5XHH7; Q6NRL6; Q9DBY1; Q8N6E8
Format
Type
Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
67685
Recommended Dilutions
WB: 1:1000
 | Western blot analysis of anti-HRD1 Pab (Cat# 102-15012) in mouse brain tissue lysate (35ug/lane). HRD1(arrow) was detected using the purified Pab. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.