Rabbit Anti-UVRAG (L133) Antibody, 400 ul
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Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human, Mouse |
| Host Species | Rabbit |
| Accession Number | Q9P2Y5 |
| Gene Id | 7405 |
| Gene Symbols | UVRAG |
| Protein Name / Synonyms | UVRAG (L133) |
| Clonality | Polyclonal |
| Preparation | This UVRAG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 120-152 amino acids from human UVRAG. |
| Concentration (lot specific) | 2.000 mg/ml |
| Recommended Applications | Western Blotting, IF, IHC-P |
| Research Area | Autophagy |
| Shipping Type | Blue ice |
| Storage | -20°C |
Introduction
UVRAG complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer.
Specificity
Other Names
UVRAG; UV radiation resistance-associated gene protein; p63
NCBI Accession #
NP_003360.2
Format
Type
Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
78151
Recommended Dilutions
WB: 1:1000; IF: Tested; IHC: 1:10-50
 | Western blot analysis of anti-hUVRAG (Center) Pab (RB10846) in mouse liver tissue lysate. hUVRAG (Center)(arrow) was detected using the purified Pab. |
 | Immunofluorescence staining of Autophagy UVRAG antibody (Cat# 102-13880) on Methanol-fixed HeLa cells. Data courtesy of Dr. Eeva-Liisa Eskelinen, University of Helsinki,Finland. |
 | Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with hUVRAG (N-term L133), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.