With the global outbreak of the novel SARS-like coronavirus, SARS-CoV-2 (2019-nCoV, COVID-19 virus) early diagnostics and infection prevention and control has become critical. Early detection leading to quarantine can significantly impact the ability of local governments to limit rapid spread to at risk patients. Scientists identified the novel coronavirus as a group 2B CoV, distinct from the SARS-CoV [1-3]. Genome sequencing indicated that SARS-CoV-2 (2019-nCoV) shares 79.5% sequence identity with SARS-CoV and 96% of identity with a bat coronavirus .
RayBiotech provides the most comprehensive technologies, tools, and products for COVID-19 clinical diagnosis, research and detection:
RayBiotech offers lateral flow devices for the detection of IgG and IgM antibodies to the coronavirus N-protein in serum, plasma, and peripheral blood. An example of a lateral flow device is a home pregnancy test. They are easy to use and provide rapid results.
This rapid test is for in vitro diagnostic use, following guidance from the FDA for Emergency Use Authorizations of tests submitted for approval on March 16, 2020. The tests have not been reviewed by the FDA and results from antibody testing should not be used as the sole basis to diagnose or exclude SARS-CoV-2 (COVID-19) infection or to inform infection status.
The spike protein (S-protein) and nucleocapsid protein (N-protein) are encoded by all coronaviruses, including the coronavirus (COVID-19) that was first detected in Wuhan City, China, in December 2019. Both recombinant forms of these proteins are now available from RayBiotech to advance infectious disease research.
Polyclonal antibodies to SARS-CoV-2.
80 tests. Suitable for the qualitative in vitro detection of novel coronavirus (SARS-CoV-2 / COVID-19) nucleic acid in patient sera and respiratory specimens (including pharyngeal swabs and alveolar lavage fluid samples).
20 tests. Suitable for the qualitative detection of new coronavirus (SARS-CoV-2 / COVID-19) nucleocapsid protein N gene in human throat swabs and alveolar lavage. Includes a one-step RT-qPCR mix. Conforms to CDC guidelines. LDT ready for high complexity CLIA labs.
Serum and plasma (EDTA) from normal (non-COVID-19) and COVID-19 patients.
The entry of the SARS-CoV-2 virus into host cell is mediated by an interaction between the Spike (S) protein’s receptor binding domain (RBD) on the surface of the viral particle and the Angiotensin I Converting Enzyme 2 (ACE2) receptor on the human cell surface. As such, this binding event is a biological target for COVID-19 therapies. The RayBio® COVID-19 Spike-ACE2 binding assay kit allows the researcher to rapidly screen and identify small molecules, antibodies, or other biological molecules that potentially interfere with the formation of the S-ACE2 complex.
COVID-19 N-Protein Human IgG, IgA, or IgM ELISA Kit - Semi-quantitative measurement of human IgG, IgA, or IgM antibody against SARS-CoV-2 N-Protein in serum or plasma sample types.
COVID-19 S-Protein (S1RBD) Human IgG, IgA, or IgM ELISA Kit - Semi-quantitative measurement of human IgG, IgA, or IgM antibody against SARS-CoV-2 S-Protein S1 subunit receptor binding domain (RBD) in serum or plasma sample types.
COVID-19 N-Protein ELISA - SARS-CoV-2 Nucleocapsid Protein ELISA Kit. Detects the N-Protein in serum, plasma, and cell culture supernatant sample types.
COVID-19 S-Protein (S2 subunit) ELISA - SARS-CoV-2 Spike Protein ELISA Kit. Detects the S-Protein (S2 subunit) in serum, plasma, and cell culture supernatant sample types.
Human ACE-2 ELISA - Human ACE-2 (angiotensin-converting enzyme 2) protein can be secreted but is also present as an integral membrane protein that serves as the initial attachment point for SARS-CoV and SARS-CoV-2 [5,6]. All coronavirus strains have a spike protein (S-protein) that mediates viral entry into the cell via interaction with ACE-2. Soluble ACE-2 has been shown to block the binding of SARS-CoV S-protein, potentially slowing down viral replication .
Semi-quantitative detection of IgM and IgG antibodies in serum or plasma to the SARS-CoV-2 (COVID-19) spike (S) protein.
During infection of the coronavirus COVID-19, high levels of inflammatory cytokines have been reported. These cytokines include interferons, interleukins, chemokines, colony-stimulating factors, and tumor necrosis factors and contribute to the symptoms of coronavirus infection: redness, swelling/edema, fever, and pain. Overproduction of pro-inflammatory cytokines can result in a “cytokine storm,” during which inflammation spreads throughout the body via the circulation. One common consequence of a cytokine storm is acute lung injury, which can progress to a more severe form called acute respiratory distress syndrome. The dynamic relationship of cytokines during inflammation can be measured using RayBiotech’s quantitative inflammation antibody arrays below. These Quantibody® arrays are a multiplex ELISA platform suitable for all liquid sample types, providing quantitative data (i.e., concentrations) of your proteins-of-interest.
|Array||Number of Targets||Targets Detected|
|Human Inflammation Array Q1||10||IL-1 alpha, IL-1 beta, IL-4, IL-6, IL-8, IL-10, IL-13, MCP-1, IFN-gamma, TNF alpha|
|Human Inflammation Array Q3||40||BLC, Eotaxin-1, Eotaxin-2, G-CSF, GM-CSF, I-309, ICAM-1, IFN-gamma, IL-1 alpha, IL-1 beta, IL-1 ra, IL-2, IL-4, IL-5, IL-6, IL-6 sR, IL-7, IL-8, IL-10, IL-11, IL-12 p40, IL-12 p70, IL-13, IL-15, IL-16, IL-17, MCP-1, M-CSF, MIG, MIP-1 alpha, MIP-1 beta, MIP-1 delta, PDGF-BB, RANTES, TIMP-1, TIMP-2, TNF alpha, TNF beta, sTNFRI, sTNFRII|
|Human Th1/Th2 Array Q1||10||GM-CSF, IFN-gamma, IL-10, IL-13, IL-2, IL-4, IL-5, IL-6, IL-8 (CXCL8), TNF alpha|
|Name||Catalog #||CAS #||Target Candidate|
|Arbidol HCl||331-11756||131707-23-8||Viral spike glycoprotein for binding to host cell receptor ACE2|
|Lopinavir||331-11643||192725-17-0||Coronavirus main protease 3CLpro|
|Ribavirin||331-10301||36791-04-5||RNA-dependent RNA polymerase|
|Chloroquine diphosphate||331-11962||54-05-7||Malaria (endosome/ACE2)|
|Nitazoxanide||331-11871||55981-09-4||Viral protein expression|
|Camostat mesilate||332-10779||59721-29-8||Transmembrane protease, serine 2, primes S protein to facilitate its binding to ACE2|
|Hydroxychloroquine Sulfate||331-21357||747-36-4||Malaria (endosome/ACE2)|
|Baricitinib Phosphate||332-10769||1187595-84-1||JAK kinase that regulate the inflammatory processes|
In the fight against coronavirus COVID-19, protein profiling can be used to understand the host response to infection and identify potential biomarkers for drug development. RayBiotech offers full testing services to measure as many as 1200 human proteins simultaneously using our quantitative Quantibody® antibody array platform.
Questions? Please contact [email protected] or at (888) 494-8555.