COVID-19 Proteins

The SARS-CoV-2 virus, which is responsible for COVID-19, comprises nearly 30 proteins, including the Spike and Nucleocapsid proteins. RayBiotech offers a comprehensive catalog of recombinant SARS-CoV-2 proteins for all domains and variants of the COVID-19 virus. Other recombinant coronavirus proteins, including SARS-CoV, MERS-CoV, and HCoV-HKU1, are also available for purchase.

Browse All COVID-19 Proteins

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The recombinant SARS-CoV-2 proteins recommended applications include ELISA, western blotting, lateral flow, antibody generation, vaccine development, and more. All recombinant proteins have a purity greater than 90% determined by SDS-PAGE under reducing conditions and visualized by Coomassie blue staining. Images are available on the product-specific pages. Multiple expression systems are available, including Human Embryonic Kidney 293 (HEK293) Cells and E.coli.

Learn about the roles SARS-CoV-2 proteins and endogenous proteins play in COVID-19 infection in our post “COVID-19 Biology 101”.

Types of COVID-19 Proteins

Spike Protein

The spike protein (S-protein) is a structural, transmembrane protein that is displayed on the surface of the viral particle.

Spike Protein Variants

SARS-CoV-2 variants have mutations within the gene encoding for the Spike (S) protein, which facilitates viral entry by binding to host receptors.

Nucleocapsid Protein

The nucleocapsid protein (N-protein) is a structural protein that binds to the coronavirus RNA genome.

Membrane Protein

The membrane protein (M-protein) is the most abundant structural protein of SARS-CoV-2.

Other Coronavirus Proteins

Recombinant SARS, MERS, and HKU1 coronavirus proteins.

Thrombosis Proteins

Inflammation associated with COVID-19 can lead to a type of thrombosis called "disseminated intravascular coagulopathy" (DIC).

Host Receptors

ACE2 is an endogenous receptor that is required for SARS-CoV-2 viral entry. Other host receptors, NRP1, AXL, CD147, GRP-78 also assist.

Browse All COVID-19 (SARS-CoV-2) Proteins

Nucleocapsid (N) Proteins:

Spike Subunit 1 (S1) Proteins:

Spike Subunit 2 (S2) Proteins:

Membrane Proteins:

Variant Proteins:

Other SARS Proteins:

S1 RBD Binding Proteins:

Thrombosis-related Proteins:

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COVID-19 Pseudovirus Service

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Catalog #	Protein Domain	Expression Region	Expression Host	Tag
230-30164	Full length	Met1 - Ala419	HEK293 Cell	C-His
230-01104	Full length	Met1 - Ala419	E.coli	N-His

Catalog #	Protein Domain	Expression Region	Expression Host	Tag
230-30162	RBD	Arg319 - Phe541	HEK293 Cell	C-His
230-30166	RBD	Arg319 - Phe541	HEK293 Cell	C-Fc
230-01102	RBD	Arg319 - Phe541	E.coli	N-His
230-01101	Full length	Val16 - Gln690	E.coli	N-His
230-30191	N-terminal	Val16-Phe318	HEK293 Cell	C-His
230-30214	N-terminal	Val16-Phe318	HEK293 Cell	C-Fc

Catalog #	Protein Domain	Expression Region	Expression Host	Tag
230-01103	Full length	Met697 - Pro1213	E.coli	N-His
230-30179	C-terminal CendR domain	Asn542-Arg685	HEK293 Cell	N-His
230-30180	C-terminal CendR domain	Asn542-Arg685	HEK293 Cell	C-Fc

Catalog #	Protein Domain	Expression Region	Expression Host	Tag
230-01124	Glycoprotein, C-terminal	Arg101-Gln222	E.coli	N-His

Catalog #	Protein Domain	Subvariant	Mutations	Expression Host	Tag
230-30157	S1 RBD		N331Q	HEK293 cell	C-His
230-30184	S1 RBD	Alpha B.1.1.7 (U.K.), Beta B.1.351 (South Africa) Gamma P.1 (Brazil).	N501Y	HEK293 cell	C-His
230-30185	S1 RBD	Alpha B.1.1.7 (U.K.), Denmark Mink Variant	Y453F	HEK293 cell	C-His
230-30186	S1 RBD	Alpha B.1.1.7 (U.K.), Beta B.1.351 (South Africa)	D614G	HEK293 cell	C-His
230-30187	S1 RBD	Alpha B.1.1.7 (U.K.)	N439K	HEK293 cell	C-His
230-30188	S1 RBD	Beta B.1.351 (South Africa), Gamma P.1 (Brazil)	E484K	HEK293 cell	C-His
230-30196	S1 RBD	Delta B.1.617.2 (India)	L452R/E484Q	HEK293 cell	C-His
230-30197	S1 RBD	Delta B.1.617.2 (India)	L452R	HEK293 cell	C-His
230-30198	S1 RBD	Delta B.1.617.2 (India)	E484Q	HEK293 cell	C-His
230-30203	S1 RBD	Delta B.1.617.2 (India)	T478K	HEK293 cell	C-His
230-30208	S1 RBD	Delta B.1.617.2 (India)	L452R/T478K	HEK293 cell	C-His
230-30209	S1 subunit, full length	Delta B.1.617.2 (India)	S1F, Y145H	HEK293 cell	C-His
230-30210	S1 subunit, full length	Delta B.1.617.2 (India)	S1F, A222V	HEK293 cell	C-His
230-30211	S1 subunit, full length	Delta B.1.617.2 (India)	S1F, Y145H/A222V	HEK293 cell	C-His
230-30206	S1 RBD	Lambda C.37 (Peru)	L452Q	HEK293 cell	C-His
230-30207	S1 RBD	Lambda C.37 (Peru)	F490S	HEK293 cell	C-His
230-30202	S1 RBD	Lambda C.37 (Peru)	L452Q/F490S	HEK293 cell	C-His
230-30212	S1 RBD	Mu B.1.621 (Colombia)	R346K	HEK293 cell	C-His
230-30213	S1 RBD	Mu B.1.621 (Colombia)	R346K/E484K/N501Y	HEK293 cell	C-His
230-30201	S1 RBD	Omicron B.1.1.529 (South Africa)	G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H	HEK293 cell	C-His
230-30218	Nucleocapsid Protein	Omicron B.1.1.529 (South Africa)	P13L, E31del, R32del, S33del, R203K, G204R	HEK293 cell	C-His
230-30018	S1 RBD	Omicron B.1.1.529 BA.2	G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H	HEK293 cell	C-His
230-30244	S1 RBD	Omicron BA.4	G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H	HEK293 cell	C-His
230-30245	S1 RBD	Omicron BA.5	G339D, S371F, S373P, S375F, T376A, D405N, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H	HEK293 cell	C-His
230-30246	S1 RBD	Omicron BA.2.75.2	G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H	HEK293 cell	C-His
230-30247	S1 RBD	Omicron XBB.1	G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H	HEK293 cell	C-His
230-30248	S1 RBD	Omicron BQ1.1	G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H	HEK293 cell	C-His

Catalog #	Species	Target	Expression Host	Tag
230-30192	SARS CoV	S1, full length	HEK293 Cell	C-His
230-30193	SARS CoV	S1, RBD	HEK293 Cell	C-His
230-30194	SARS CoV	Nucleocapsid Protein	HEK293 Cell	C-His
230-30195	MERS CoV	S1, full length	HEK293 Cell	C-His
230-30204	MERS CoV	S1, RBD	HEK293 Cell	C-His
230-30205	MERS CoV	Nucleocapsid Protein	HEK293 Cell	C-His
230-30199	HCov-HKU1	S1, full length	HEK293 Cell	C-His
230-30200	HCov-HKU1	S1, RBD	HEK293 Cell	C-His

Catalog #	Species	Target	Accesion #	Expressed Region	Expression Host	Tag
230-30165	Human	ACE2	Q9BYF1	Gln18 - Ser740	HEK293 Cell	C-His
230-30177	Mouse	ACE2	Q8R0I0	Gln18-Thr740	HEK293 Cell	C-His
230-30176	Human	NRP1, isoform 2	O14786-2	Phe22-Lys644	HEK293 Cell	C-His
230-30178	Human	NRP1, isoform 1	O14786-1	Phe22-Pro856	HEK293 Cell	C-His
230-30189	Human	NRP1, isoform 1 mutant (S346A, E348A, T349A)	O14786-1	Phe22-Pro856	HEK293 Cell	C-His
230-30100	Human	GRP-78	P11021	Glu19-Leu654	HEK293 Cell	C-His
230-30181	Human	BASIGIN, BSG	P35613-2	Thr28-Leu206	HEK293 Cell	C-His
230-30190	Human	AXL	P30530	Ala26-Trp451	HEK293 Cell	C-His

Catalog #	Species	Target	Accesion #	Expressed Region	Expression Host	Tag
230-30170	Coagulation factor II (F2), Thrombin	Human	HEK293 Cell	P00734	Full length	N-His
230-30063	SERPINE1	Mouse	HEK293 Cell	Q7TPE9	Full length	N-His
230-30042	SERPINE1	Mouse	HEK293 Cell	P97298	Full length	N-His
230-30171	Serpin F2	Human	HEK293 Cell	P08697	Asn40-Lys491	N-His

COVID-19 Proteins | RayBiotech

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COVID-19 Proteins

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