Cardiotrophin-1 (CT-1) is a cardiac hypertrophic factor and belongs to the IL-6 cytokine family.The protein interacts with the glycoprotein 130 (gp130)/leukemia inhibitory factor receptor beta (LIFR)heterodimer. CT-1 deficiency causes increased motoneuron cell death in spinal cord and brainstemnuclei of mice. In addition, CT-1 enhances transcription factor NF kappa B DNA-binding activities andactivates phosphatidylinositol 3-kinase (PI-3 kinase) in cardiac myocytes. Studies have revealed CT-1 ishighly expressed in the heart, prostate, skeletal muscle, and ovary, and expressed at the lower levels inlung, kidney, pancreas, thymus, small intestine, and testis. CT-1 is highly secreted by myotubes, andpromotes the survival of cultured embryonic mouse and rat MNs. CT-1 is associated withpathophysiology of heart diseases, like hypertension, myocardial infarction, valvular heart disease, andcongestive heart failure.

The antibody is stable for at least 1 year from the date of receipt when stored at -20°C to -70°C. Reconstituted antibody can also be aliquotted and stored at 4°C for 1 month or at -20°C to -70°C in a manual defrost freezer for many months without detectable loss activity. Please avoid freeze-thaw cycles.

Rabbit anti-Human Cardiotrophin-1 antibody detects specifically target derived from humanrecombinant protein as well as HepG2 cell lysates. Cross reactivity with mouse and rat CT-1 was nottested yet.

Human Cardiotrophin-1 (CT-1) ELISA Kit For Serum, Plasma, Cell Culture Supernatant and Urine(Cat# ELH-CT1-001 ); Recombinant Human Cardiotrophin-1 (Cat# 230-00008)