The SARS-CoV-2 virus, which is responsible for COVID-19, is comprised of nearly 30 proteins, including the Spike and Nucleocapsid proteins (see figures below). RayBiotech offers a comprehensive catalog of recombinant SARS-CoV-2 proteins.
Like SARS-CoV-2, other coronaviruses can cause respiratory tract infections, including SARS-CoV, the Middle East respiratory syndrome coronavirus (MERS-CoV), and the human coronavirus HKU1 (HCoV-HKU1).
Angiotensin I Converting Enzyme 2 (ACE2) is an endogenous receptor that is required for SARS-CoV-2 viral entry. Other host receptors, Neuropilin-1 (NRP1), Tyrosine Kinase Receptor UFO (AXL), Basignin (or CD147), and Heat Shock Protein Family A Member 5 (GRP-78) have also been demonstrated to assist in SARS-CoV-2 entry.
The inflammation associated with SARS-CoV-2 infection can cause disseminated intravascular coagulopathy (DIC), leading to obstruction of the blood vessels of lung, heart and kidneys. Initially, DIC in COVID-19 patients presents with abnormalities in prothrombin time, partial thromboplastin time, and platelet counts.
For help identifying the right protein for your research, please contact our technical support team at [email protected] or (888) 494-8555.